One annoyance when I installed Vista on my development machine at home was that I could no longer debug my ASP.NET apps, due in large part to this error:
“An authentication error occurred while communicating with the web server.”
Lots of searching got me to an article by Mike Volodarsky on using various workarounds but I just saw on Scott Guthrie’s blog that there is now there is a better solution out there, a patch for Visual Studio 2005.
The patch can be downloaded here.